Bottom line: latex glove allergy is caused by residual natural rubber proteins. EN 455-3 sets a limit of 200 μg/dm² for extractable protein (the “low protein” threshold), and many buyers specify 50 μg/dm² or lower. Choosing powder-free gloves, chlorinated or polymer-coated, sharply reduces airborne protein exposure.
Latex allergy is one of the most important safety considerations when purchasing latex examination gloves. It is caused by residual proteins left in natural rubber during manufacturing. Understanding protein limits — and specifying low-protein, powder-free gloves — protects both your staff and your customers. Here is what every buyer should know.
What Causes Latex Allergy?
Natural rubber latex contains proteins that can leach out of the glove during use. Repeated skin contact, or inhalation of powder that carries these proteins into the air, can sensitize some people and lead to an allergic reaction ranging from skin irritation (Type IV) to, rarely, a severe systemic response (Type I).
For a buyer’s view of the difference between Type I and Type IV reactions, see our guide.
The 200 μg/dm² Protein Limit
The European standard EN 455-3 sets a maximum extractable protein content of 200 micrograms per square decimetre (μg/dm²) for latex gloves. Gloves that meet this limit are classified as “low protein”. Many hospital procurement policies and government tenders specify an even stricter limit, often 50 μg/dm² or lower.
Why Powder-Free Matters
Powdered gloves use cornstarch that can bind to latex proteins and release them into the air when gloves are snapped on or removed. This airborne protein is a major route of sensitization. Powder-free gloves, which use chlorination or a polymer coating instead, dramatically reduce this risk.
How Pacific Resource Global Controls Protein Levels
Pacific Resource Global latex examination gloves are manufactured to meet the EN 455-3 low-protein threshold of under 200 μg/dm². We offer both powdered and powder-free finishes, with powder-free gloves treated by chlorination or polymer coating to minimise residual protein and powder. Every batch is produced under ISO 13485:2016 quality management.
Certifications That Back the Safety Claims
Our only EU Type-Examination CE is BRI-47173-A for powdered latex under EU PPE Regulation 2016/425 (Category III), tested to EN ISO 374-1:2016 Type B and EN ISO 374-4:2019. The factory also holds ISO 9001. These certificates are available on request so you can verify protein and quality claims independently.
Specifying Low-Protein Gloves for Your Next Tender?
Contact info@pacificresourceglobal.com for certificates, batch test data and a quote.
Sources and standards
The requirements referenced in this article come from the following public standards and regulations:
- ASTM D3578 – Standard Specification for Rubber Examination Gloves
- European Commission – harmonised standards for medical devices (EN 455 series)
- European Commission – Personal Protective Equipment Regulation (EU) 2016/425
When you draft your tender, you can review the gloves themselves in our latex glove range.